11/16/2023 0 Comments Flat io is loading a blank screenSo, for those who want to do that, I generally would not recommend it. They will actually continue to give 6 cycles of chemotherapy along with immunotherapy before they switch to a maintenance setting. We know some of our colleagues, I don't do that, but I'm aware of some of our colleagues who, with the usual practice of wanting to give as many cycles as possible of chemotherapy that's working before they stop. As we all remember from the CASPIAN trial, the control arm on chemotherapy alone was actually allowed to get up to 6 cycles. Now, the other thing is, Dr Sands mentioned this before in terms of the number of cycles of treatment to be given. I think we could all be confident now that even in patients who would otherwise not be considered protocol eligible but treated in the real world, the benefit of adding immunotherapy to chemotherapy was comparable to what you would find in patients who are enrolled on the trial. ![]() Some people use flat iron data, other people use institutional or registry data. And we always ask ourselves, how relevant would this data be to our day-to-day regular patient walking into our clinic, where you are now going through the detailed eligibility criteria that were required by the protocol? I think in that regard, there are now, at least, whether in abstract from a full publication, several publications showing that in the real-world, patients treated with this regimen, not in the context of a defined rigorous clinical trial. Owonikoko, MD, PhD: It's important to recognize, as we're looking at data, these are really well-selected rarefied patient subgroups that went on the clinical trials.
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